Demographic and global cognitive characteristics of the participants.

<p>Note: Values are given in mean (SD). MMSE^a, mini-mental state examination. (M/W) M, male; W, women. WAIS: Wechsler Adult Intelligence Scale. RAVLT: Rey-Auditory Verbal Learning test (delayed recall). VR-WMS-R: Visual Reproduction, Wechsler Memory Scale Revised (delayed recall). t = Student's test. U = U-Mann Whitney test.</p

Effects of rTMS in the DMN present in deactivation task-related networks.

<p>While both groups exhibited increased temporal correlations between the timecourse of this network and rest condition after rTMS, its activity (intensity of the expression) clearly diverged. In the bar graphs it is shown that DMN activity decreased for ε4 non-carriers whereas increased for the ε4-carriers. Corr: Correlation values (r-Pearson) between the timecourse of each network and the ‘resting condition’. Intensity values are thresholded at z = 2.3. Coordinates are given in MNI (x = −4, z = 26). A.U = arbitrary units.</p

Effects of rTMS in the DMN present in deactivation task-related networks.

<p>While both groups exhibited increased temporal correlations between the timecourse of this network and rest condition after rTMS, its activity (intensity of the expression) clearly diverged. In the bar graphs it is shown that DMN activity decreased for ε4 non-carriers whereas increased for the ε4-carriers. Corr: Correlation values (r-Pearson) between the timecourse of each network and the ‘resting condition’. Intensity values are thresholded at z = 2.3. Coordinates are given in MNI (x = −4, z = 26). A.U = arbitrary units.</p

Brain Networks related with encoding and subsequent memory performance.

<p>Brain Networks related with encoding and subsequent memory performance.</p

Measures of recognition memory before (pre) and after (post) rTMS.

<p>Values are given in mean (ranges). t = repeated measures t test comparing pre vs post rTMS in the whole sample. F = results of the interaction value of the two-factor ANOVA using genetic subgroup as the between subject factor and moment of the evaluation (PRE vs POST) as within subject factor.</p

Independent components (networks) that were significantly correlated with the deactivation period (DTBRP = deactivation-task brain related pattern).

<p>Networks are separated for each condition (pre-post TMS) and group (ε4 carriers-noncarriers). DTRP = Dectivation Task Related Patterns. Coordinates are given in MNI space. Intensity values are thresholded at z = 2.3. Brain areas of each network are fully described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0051833#pone-0051833-t004" target="_blank">table 4</a>.</p

Independent components (IC, networks) that were highly correlated with the encoding period and performance (ATBRP = activation-task brain related pattern).

<p>Networks are separated for each condition (pre-post TMS) and group (ε4 carriers-noncarriers). Coordinates are given in MNI space. Intensity values are thresholded at z = 2.3. Brain areas of each network are fully described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0051833#pone-0051833-t003" target="_blank">table 3</a>.</p

Brain Networks related with deactivation.

<p>Brain Networks related with deactivation.</p

Socio-demographic, clinical and cognitive characteristics of the sample.

<p>Socio-demographic, clinical and cognitive characteristics of the sample.</p

Resting-state components.

<p>Resting-state components.</p